Our Publications
Dissecting the possible role of Mesenchymal Stromal Cells in the orthopaedic and odontostomatological research fields
Nitrogen Containing Bisphosphonates Impair The Release Of Bone Homeostasis Mediators And Matrix Production By Human Primary Pre-Osteoblasts. Giannasi C, Niada S, Farronato D, Lombardi G, Manfredi, Farronato G and Brini AT. Int J of Med Sci. 2019; 16(1): 23-32. doi:10.7150/ijms.27470.
Impact of Dental Implant Surface Modifications on Adhesion and Proliferation of Primary Human Gingival Keratinocytes and Progenitor Cells. Giannasi C, Pagni G, Polenghi C, Niada S, Manfredi B, Brini AT, Rasperini G. Int J Periodontics Restorative Dent. 2018 Jan/Feb;38(1):127-135. doi: 10.11607/prd.3304. PubMed PMID: 29240214.
17β-estradiol differently affects osteogenic differentiation of mesenchymal stem/stromal cells from adipose tissue and bone marrow. Niada S, Giannasi C, Ferreira LM, Milani A, Arrigoni E, Brini AT. Differentiation. 2016 Dec;92(5):291-297. doi: 10.1016/j.diff.2016.04.001. Epub 2016 Apr 14. PubMed PMID: 27087652.
Human Adipose-Derived Stem Cells on Rapid Prototyped Three-Dimensional Hydroxyapatite/Beta-Tricalcium Phosphate Scaffold. Canciani Elena, Dellavia Claudia, Ferreira Lorena Maria, Giannasi Chiara, Carmagnola Daniela, Carrassi Antonio, Brini Anna Teresa. J Craniofac Surg. 2016 May;27(3):727-32. doi: 10.1097/SCS.0000000000002567. PubMed PMID: 27092915.
Effect of an Activated Platelet Concentrate on Differentiated Cells Involved in Tissue Healing. Brini AT, Ceci C, Taschieri S, Niada S, Lolato A, Giannasi C, Mortellaro C, Del Fabbro M. J Craniofac Surg. 2016 Apr 5. [Epub ahead of print] PubMed PMID: 27054419.
Does Freeze-Thawing Influence the Effects of Platelet Concentrates? An In Vitro Study on Human Adipose-Derived Stem Cells. Ceci C, Niada S, Del Fabbro M, Lolato A, Taschieri S, Giannasi C, Brini AT. J Craniofac Surg. 2016 Feb 10. [Epub ahead of print] PubMed PMID: 26872279.
Hypoxia promotes the inflammatory response and stemness features in visceral fat stem cells from obese subjects. Petrangeli E, Coroniti G, Brini AT, de Girolamo L, Stanco D, Niada S, Silecchia G, Morgante E, Lubrano C, Russo MA and Salvatori L. J Cell Physiol. 2016 Mar;231(3):668-79. doi: 10.1002/jcp.25113
Repair of osteochondral defects in the minipig model by OPF hydrogel loaded with adipose-derived mesenchymal stem cells. de Girolamo L, Niada S, Arrigoni E, Di Giancamillo A, Domeneghini C, Dadsetan M, Yaszemski MJ, Gastaldi D, Vena P, Taffetani M, Zerbi A, Sansone V, Peretti GM, Brini AT. Regen Med. 2015 Mar;10(2):135-51.
Characterization and functional analyses of Mesenchymal stromal cell secretome and its sub-components
Adipose-derived stromal cell secretome reduces TNFα-induced hypertrophy and catabolic markers in primary human articular chondrocytes. Niada S, Giannasi C, Gomarasca M, Stanco D, Casati S , Brini A T Stem Cell Research 2019 May 15;38:101463. doi: 10.1016/j.scr.2019.101463.
Raman spectroscopy as a quick tool to assess purity of extracellular vesicle preparations and predict their functionality. Gualerzi G, Kooijmans SAA, Niada S, Picciolini S, Brini AT, Camussi G & Bedoni M. doi: 10.1080/20013078.2019.1568780
Differential Proteomic Analysis Predicts Appropriate Applications for the Secretome of Adipose-Derived Mesenchymal Stem/Stromal Cells and Dermal Fibroblasts. Niada S*, Giannasi C*, Gualerzi A, Banfi G, Brini AT. Stem Cells International Volume 2018, ID 7309031, doi:10.1155/2018/7309031
Raman spectroscopy uncovers biochemical tissue-related features of extracellular vesicles from mesenchymal stromal cells. Gualerzi A, Niada S, Giannasi C, Picciolini S, Morasso C, Vanna R, Rossella V, Masserini M, Bedoni M, Ciceri F, Bernardo ME, Brini AT, Gramatica F. Sci Rep. 2017 Aug 29;7(1):9820. doi:10.1038/s41598-017-10448-1. PubMed PMID: 28852131.
Therapeutic effect of human adipose-derived stem cells and their secretome in experimental diabetic pain. Brini AT, Amodeo G, Ferreira LM, Milani A, Niada S, Moschetti G, Franchi S, Borsani E, Rodella LF, Panerai AE, Sacerdote P. Sci Rep. 2017 Aug 29;7(1):9904. doi: 10.1038/s41598-017-09487-5. PubMed PMID: 28851944.
Mesenchymal stem/stromal cell extracellular vesicles: From active principle to next generation drug delivery system. Crivelli B, Chlapanidas T, Perteghella S, Lucarelli E, Pascucci L, Brini AT, Ferrero I, Marazzi M, Pessina A, Torre ML; Italian Mesenchymal Stem Cell Group (GISM). J Control Release. 2017 Jul 20;262:104-117. doi:10.1016/j.jconrel.2017.07.023. [Epub ahead of print] Review. PubMed PMID: 28736264.
Mesenchymal Stromal Cells as vehicles for drug delivery
In Vitro Anticancer Activity of Extracellular Vesicles (EVs) Secreted by Gingival Mesenchymal Stromal Cells Primed with Paclitaxel. Coccè V, Franzè S, Brini AT, Giannì A B, Pascucci L, Ciusani E, Alessandri G, Farronato G, Cavicchini L, SordiV, Paroni R, Dei Cas M, Cilurzo Fand Pessina A. Pharmaceutics. Pharmaceutics 2019, 11, 61; doi:10.3390/pharmaceutics11020061.
Human Olfactory Bulb Neural Stem Cells (Hu-OBNSCs) Can Be Loaded with Paclitaxel and Used to Inhibit Glioblastoma Cell Growth. Marei HE, Casalbore P, Althani A, Coccè V, Cenciarelli C, Alessandri G, Brini AT, Parati E, Bondiolotti G, Pessina A. Pharmaceutics. 2019 Jan 21;11(1). pii: E45. doi: 10.3390/pharmaceutics11010045. PubMed PMID: 30669623
Microfragmented human fat tissue is a natural scaffold for drug delivery: Potential application in cancer chemotherapy. Alessandri G, Coccè V, Pastorino F, Paroni R, Dei Cas M, Restelli F, Pollo B, Gatti L, Tremolada C, Berenzi A, Parati E, Brini AT, Bondiolotti G, Ponzoni M, Pessina A. J Control Release. 2019 May 28;302:2-18. doi: 10.1016/j.jconrel.2019.03.016. Epub 2019 Mar 16.
Uptake-release by MSCs of a cationic platinum(II) complex active in vitro on human malignant cancer cell lines. Rimoldi I, Coccè V, Facchetti G, Alessandri G, Brini AT, Sisto F, Parati E, Cavicchini L, Lucchini G, Petrella F, Ciusani E, Pessina A. Biomed Pharmacother. 2018 Dec;108:111-118. doi: 10.1016/j.biopha.2018.09.040. Epub 2018 Sep 12.
Drug loaded gingival mesenchymal stromal cells (ginpa-mscs) inhibit in vitro proliferation of oral squamous cell carcinoma. Coccè V, Farronato D, Brini AT, Masia C, Giannì AB, Piovani G, Sisto F, Alessandri G, Angiero F, Pessina A. Scientific Reports. 2017 Aug 24;7(1):9376. doi: 10.1038/s41598-017-09175-4. PubMed PMID: 28839168.
Effect of canine mesenchymal stromal cells loaded with paclitaxel on growth of canine glioma and human glioblastoma cell lines. Bonomi A, Ghezzi E, Pascucci L, Aralla M, Ceserani V, Pettinari L, Coccè V, Guercio A, Alessandri G, Parati E, Brini AT, Zeira O, Pessina A. Vet J. 2017 May;223:41-47. doi: 10.1016/j.tvjl.2017.05.005. Epub 2017 May 19. PubMed PMID: 28671070.
Fluorescent immortalized human adipose derived stromal cells (hASCs-TS/GFP+) for studying cell drug delivery mediated by microvesicles. Coccè V, Balducci L, Falchetti ML, Pascucci L, Ciusani E, Brini AT, Sisto F, Piovani G, Alessandri G, Parati E, Cabeza L, Pessina A. Anticancer Agents Med Chem. 2017 Mar 27. doi: 10.2174/1871520617666170327113932
Paclitaxel-releasing mesenchymal stromal cells inhibit in vitro proliferation of human mesothelioma cells. Petrella F, Coccè V, Masia C, Milani M, Salè EO, Alessandri G, Parati E, Sisto F, Pentimalli F, Brini AT, Pessina A, Spaggiari L. Biomed Pharmacother. 2017 Mar;87:755-758. doi: 10.1016/j.biopha.2017.01.118.
Cell-mediated drug delivery by gingival interdental papilla mesenchymal stromal cells (GinPa-MSCs) loaded with paclitaxel. Brini AT, Coccè V, Ferreira LM, Giannasi C, Cossellu G, Giannì AB, Angiero F, Bonomi A, Pascucci L, Falchetti ML, Ciusani E, Bondiolotti G, Sisto F, Alessandri G, Pessina A, Farronato G. Expert Opin Drug Deliv. 2016 Apr 5:1-10. [Epub ahead of print] PubMed PMID: 26986001.
Genetic alterations in rare bone tumors
Comprehensive Molecular Characterization of Adamantinoma and OFD-like Adamantinoma Bone Tumors. Ali NM, Niada S, Morris MR, Brini AT, Huen D, Sumathi V, Latif F.Am J Surg Pathol. 2019 Jul;43(7):965-974. doi: 10.1097/PAS.0000000000001251.
Genomic and transcriptomic characterisation of undifferentiated pleomorphic sarcoma of bone. Ali NM, Niada S, Brini AT, Morris MR, Kurusamy S, Alholle A, Huen D, Antonescu CR, Tirode F, Sumathi V, Latif F.J Pathol. 2019 Feb;247(2):166-176. doi: 10.1002/path.5176. Epub 2018 Dec 27.
Genetic analyses of undifferentiated small round cell sarcoma identifies a novel sarcoma subtype with a recurrent CRTC1-SS18 gene fusion. Alholle A, Karanian M, Brini AT, Morris MR, Kannappan V, Niada S, Niblett A, Ranchère-Vince D, Pissaloux D, Delfour C, Maran-Gonzalez A, Antonescu CR, Sumathi V, Tirode F, Latif F.J Pathol. 2018 Jun;245(2):186-196. doi: 10.1002/path.5071. Epub 2018 Apr 16.
Diagnostic Utility of IDH1/2 Mutations to Distinguish Dedifferentiated Chondrosarcoma from Undifferentiated Pleomorphic Sarcoma of Bone. Chen S, Fritchie K, Wei S, Ali N, Curless K, Shen T, Brini AT, Latif F, Sumathi V, Siegal GP, Cheng L. Hum Pathol. 2017 Jul;65:239-246. doi:10.1016/j.humpath.2017.05.015. Epub 2017 May 25. PubMed PMID: 28552826.
Genome-wide DNA methylation profiling of recurrent and non-recurrent chordomas. Alholle A, Brini AT, Bauer J, Gharanei S, Niada S, Slater A, Gentle D, Maher ER, Jeys L, Grimer R, Sumathi VP, Latif F. Epigenetics. 2015 Mar 4;10(3):213-20.