TISSUE ENGINEERING AND BIOMATERIALS LAB
Director: Prof. Giuseppe M. Peretti
Laura Mangiavini
Bio
Dr. Laura Mangiavini is an orthopaedic surgeon, but she’s always also been interested in basic research on cartilage and bone. Thus, after graduation and specialization, she spent few years in Ernestina Schipani’s laboratory where she deepened her knowledge in cartilage and bone development working on transgenic mouse models. Back in Italy, she is an attending surgeon at IRCCS Istituto Ortopedico Galeazzi and she is also actively working in the lab on the development of novel strategies for cartilage and bone tissue engineering.
Publications
1. Scotti C, Mangiavini L, Boschetti F, Vitari F, Domeneghini C, Fraschini G, Peretti GM.
Effect of in vitro culture on a chondrocyte-fibrin glue hydrogel for cartilage repair. Knee
Surg Sports Traumatol Arthrosc. 2010 Oct;18(10):1400-6
2. Aro E, Khatri R, Gerard-O'Riley R, Mangiavini L, Myllyharju J, Schipani E. Hypoxia-inducible factor-1 (HIF-1) but not HIF-2 is essential for hypoxic induction of collagen prolyl 4-hydroxylases in primary newborn mouse epiphyseal growth plate chondrocytes. J Biol Chem. 2012 Oct 26;287(44):37134-44
3. Mangiavini L, Merceron C, Araldi E, Khatri R, Gerard-O'Riley R, Wilson TL, Rankin EB, Giaccia AJ, Schipani E. Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development. Dev Biol. 2014 Sep 1;393(1):124-36
4. Merceron C, Mangiavini L, Robling A, Wilson TL, Giaccia AJ, Shapiro IM, Schipani E,
Risbud MV. Loss of HIF-1α in the notochord results in cell death and complete disappearance of the nucleus pulposus. PLoS One. 2014 Oct 22;9(10):e110768
5. Mangiavini L, Merceron C, Araldi E, Khatri R, Gerard-O'Riley R, Wilson TL, Sandusky G, Abadie J, Lyons KM, Giaccia AJ, Schipani E. Fibrosis and Hif1a-dependent tumors of the soft tissue upon loss of Vhl in mesenchymal progenitors. Am J Pathol 2015 185, 3090-3101
6. Agarwal S, Loder S, Brownley C, Cholok D, Mangiavini L, Li J, Breuler C, Sung HH, Li S, Ranganathan K, Peterson J, Tompkins R, Herndon D, Xiao W, Jumlongras D, Olsen BR, Davis TA, Mishina Y, Schipani E, Levi B. Inhibition of Hif1α prevents both trauma-induced and genetic heterotopic ossification. Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):E338-47. doi: 10.1073/pnas.1515397113. Epub 2015 Dec 31
7. Choi H, Merceron C, Mangiavini L, Seifert EL, Schipani E, Shapiro IM, Risbud MV. Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling. Autophagy. 2016 Sep;12(9):1631-46
8. Wang H, Lindborg C, Lounev V, Kim JH, McCarrick-Walmsley R, Xu M, Mangiavini L, Groppe JC, Shore EM, Schipani E, Kaplan FS, Pignolo RJ. Cellular Hypoxia Promotes Heterotopic Ossification by Amplifying BMP Signaling. J Bone Miner Res. 2016 Sep;31(9):1652-65
9. Peretti GM, Tessaro I, Montanari L, Polito U, Di Giancamillo A, Di Giancamillo M, Marmotti A, Montaruli A, Roveda E, Mangiavini L. Histological changes of the meniscus following an osteochondral lesion. J Biol Regul Homeost Agents. 2017 Oct-Dec,;31(4 suppl 1):129-134.
10. Fisher JN, Tessaro I, Bertocco T, Peretti GM, Mangiavini L. The Application of Stem
Cells from Different Tissues to Cartilage Repair. Stem Cells Int. 2017;2017:2761678. doi: 10.1155/2017/2761678. Epub 2017 Dec 10. Review.