The development of advanced systems for the in vitro culture of 3D constructs is one of the main expertise of the Cell and Tissue Engineering Laboratory. In particular, we design and develop custom-built miniaturized models, including microfluidic systems, as well as macroscale bioreactors for the dynamic culture of 3D constructs. The development of in vitro cell culture systems is based on an integrated experimental-computational approach applying computational simulations to drive the design process. In particular, we develop miniaturized models and bioreactors for the dynamic culture and biophysical stimulation of 3D constructs for bone, cartilage, muscle, and tendon tissue engineering.

Along with in vitro models, we develop animal models meeting taxonomic equivalency to humans and resembling human physiology and response to treatments in the orthopedic field. Our main preclinical models are related to osseointegration, osteochondral defects, implant-related infections, tendon diseases, etc.